Fasting has been shown to promote cellular repair, improve metabolic health, and support longevity, yet traditional fasting can be difficult to maintain. The ProLon Fasting-Mimicking Program (FMD) offers a science-based, convenient alternative that delivers many of fasting’s physiological benefits while still allowing small amounts of food.
How ProLon Works
Developed by Dr. Valter Longo and researchers at the University of Southern California, ProLon is a five-day, plant-based, nutrient-calibrated program designed to place the body in a fasting state while maintaining essential nourishment. Each day’s meals and snacks are pre-packaged and carefully formulated with specific ratios of healthy fats, complex carbohydrates, and minimal protein.
This precise nutrient balance “tricks” the body into sensing nutrient scarcity, activating the same cellular pathways that respond to fasting. During this process, the body reduces activity in growth pathways such as IGF-1 and mTOR, and shifts energy metabolism from glucose to fat. This metabolic switch promotes autophagy (the cleanup and renewal of damaged cells) and enhances mitochondrial function – key processes for healthy aging and metabolic balance.
Clinical Benefits
Clinical studies of the fasting-mimicking diet have shown measurable improvements in several important health markers:
- Reduction in abdominal and visceral fat
- Improved insulin sensitivity and lower average blood sugar levels (A1C)
- Decreased LDL (“bad”) cholesterol and triglycerides
- Lower blood pressure and inflammatory markers
- Reduced IGF-1, a hormone linked with aging and cellular stress
- Activation of genes associated with cellular repair and longevity
In a 2024 University of Southern California study, participants who completed three to four cycles of ProLon showed an average biological age reduction of 2.5 years.
Benefits for Patients with Elevated A1C or Cholesterol
For patients with prediabetes, elevated A1C, or high cholesterol, ProLon can help reset metabolic function. By promoting fat metabolism and improving insulin efficiency, the program helps stabilize blood sugar while supporting healthy lipid levels. Many patients report decreased cravings for sugar and processed foods, as well as improved energy and focus after completing a cycle.
Simple and Convenient
Each ProLon kit provides five days of pre-portioned, shelf-stable meals, soups, teas, and snacks. There is no need to shop, measure, or count calories – you simply consume the contents of each daily box and stay hydrated. Most patients find it easier to complete than traditional fasting, with improved energy and mental clarity by day three.
Safety and Considerations
ProLon is not recommended during pregnancy, breastfeeding, or for individuals with certain medical conditions. Patients taking prescription medications, especially for diabetes or blood pressure, should consult their healthcare provider before beginning the program.
In Summary
The ProLon Fasting-Mimicking Program is a clinically tested, convenient way to support metabolic health, reduce A1C and cholesterol levels, and activate the body’s natural cellular renewal processes — all while consuming nourishing, plant-based foods.
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Disclaimer: As a certified ProLon provider, I may earn a commission from qualifying purchases. I share this program because I’ve seen its benefits firsthand and use it with my clients. Always consult your healthcare provider before beginning any fasting or dietary program.
Each Prolon cycle helps you lose fat, protect muscle, and rejuvenate at the cellular level, so you feel lighter, clearer, and more energized – with cycles building upon each other for maximum results.
Stay consistent, multiply the benefits
Three consecutive 5-Day cycles have been shown to reduce biological age by 2.5 years, improve skin hydration and radiance, and support healthy cardiometabolic markers.
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